A 4-year Ph.D. studentship, starting in January 2019, is available in the area of transition-metal catalysis, focusing on the development of novel deuteration methodology for biomolecules and drug targets. The studentship, which is funded by the College of Science, NUI Galway, covers EU tuition fees and includes a tax-free annual salary of €12,000. Candidates will be expected to hold a Master’s degree or a very good Bachelor’s degree in a related area before the start of the studentship.
Interested candidates are asked to submit a full application containing a cover letter, CV, and two letters of recommendation to miriam.oduill(at)nuigalway.ie or by post to Dr. Miriam O’Duill, School of Chemistry, NUI Galway, University Road, Galway, H91 TK33, Ireland by December 18th 2018. Informal enquiries are welcome at any time.
Project description: Deuteration of bioactive molecules is a crucial tool for biomolecular analysis techniques (neutron diffraction, 2D NMR, hydrogen exchange mass spectroscopy) and the pharmaceutical industry (ADME studies, deuterated drugs). A diverse toolkit of synthetic methods is necessary to selectively install deuterium isotopes in the molecules and positions of interest. This Ph.D. project will focus on the development of transition-metal catalysed C–H activation / deuteration strategies to afford deuterated analogues of bioactive molecules or drugs that currently require expensive, multi-step syntheses. The research will involve screening for methodology development and organic synthesis of small molecules. The work will be carried out at the School of Chemistry, NUI Galway, Ireland (http://www.nuigalway.ie/chemistry/), in the research group of Dr. Miriam O’Duill, who was recently appointed as lecturer in organic chemistry.
After waiting patiently for all of our chemicals to arrive, Maria Moran – who is doing her 4th year project in the O’Duill group – beat the lads to it and set up her first reaction. She also provided us with a good stock of TLC spotters. Here’s to lots more exciting chemistry!
Arann Drohan has just graduated from the Waterford Institute of Technology with a B.Sc. (Hons) in Pharmaceutical Science, which included a final year research project on polymeric drug delivery platforms. Arann is keen to apply his knowledge to developing novel, more easily cleavable directing groups for C–H activation during his M.Sc.
After graduating with a B.Sc. (Hons) in Pharmaceutical and Biomedical Chemistry from Maynooth University, Liam Fitzgerald joins the group on a prestigious SFI PhD scholarship. In collaboration with CÚRAM, Liam will be investigating new ion-responsive drug delivery platforms. We’re excited to have him on the team!
Miriam’s research stay at the MPIP came to a successful end yesterday. Special thanks to Prof. Katharina Landfester, Dr. Frederik Wurm and the entire Landfester group for a great summer of science and fun. I look forward to further collaborations! (Photo credit: Young-Gon Kim)
SFI PhD Scholarship: Ion-responsive self-immolative linkers for drug delivery
A 4-year PhD scholarship is available in the O’Duill group, School of Chemistry, NUI Galway. The multidisciplinary project will investigate selective drug delivery to ion channels by designing ion-responsive self-immolative linkers for hyaluronic acid drug conjugates and lies at the interface of synthetic chemistry, polymer chemistry, materials and biochemistry. The research programme will be carried out in collaboration with the Centre for Research in Medical Devices (CÚRAM)—a national, SFI-funded, €49.6m research centre—and will encourage networking and strong clinical and industrial collaborations. The successful candidate will be provided with training and development opportunities designed to support his/her personal career development plans.
The scholarship, funded by CÚRAM, includes EU tuition fees, an annual stipend of €18,500 and a contribution to training and travel. Candidates will be expected to hold a Master’s degree in Chemistry and experience in synthetic organic chemistry is highly desirable. The starting date of the scholarship is September 1st 2018.
For more details, click here.
Interested candidates should submit an application including a cover letter, CV, and two letters of recommendation to miriam.oduill(at)nuigalway.ie by August 10th 2018.
Miriam is excited to be spending the next three months at the Max Planck Institute for Polymer Research in Mainz, expanding her research into polymer and materials chemistry under the guidance of Prof. K. Landfester and Dr. F. Wurm.